The special will center on Gwen Stacy/Ghost-Spider (Dove Cameron), who is accidentally framed for her friend's murder. She is soon tracked down by a roster of heroes like Kamala Khan/Ms. Marvel (Kathleen Khavari), Doreen Green/Squirrel Girl (Milana Vayntrub), Rayshaun Lucas/Patriot (Kamil McFadden), and Daisy Johnson/Quake (Chloe Bennet).